Dewi Irawati Soeria Santoso, Imelda Rosalyn Sianipar, Neng Tine Kartinah


In recent years, the prevalence of obesity continues to increase, leading to a public health problem. Therefore, the obesity problem needs serious attention and treatment approaches. Exercise is one of the treatment approach to combat obesity because exercise plays a role in beiging/browning process. Beiging is a differentiation process from white adipocyte to beige adipocyte, which has similar characteristics to brown adipocyte and is marked with an increase of UCP-1 expression. Irisin plays a role in increasing UCP-1 expression by activating p38 mitogen-activated protein kinase (MAPK) and extracellular-signal regulated kinase (ERK) signaling. Muscle contraction during exercise can activate PGC-1α, which leads to the synthesis of irisin. Exercise may increase irisin levels in skeletal muscle and consequently, play as a mediator of beiging process in adipose tissue.


beiging of adipose, exercise, irisin, UCP-1

Full Text:



WHO. Priority diseases and reasons for inclusion [Internet]. [cited 2018 Nov 29];Available from:

Liu X, Cervantes C, Liu F. Common and distinct regulation of human and mouse brown and beige adipose tissues: a promising therapeutic target for obesity. Protein Cell. 2017;8(6):446

Kesehatan BPDP, RI kk. pokok riset kesehatan dasar provinsi

Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and fitness: definitions and distinctions for health-related research. 1985;100(2):126–31.

Rocha-Rodrigues S, Rodríguez A, Gouveia AM, Gonçalves IO, Becerril S, Ramírez B, et al. Effects of physical exercise on myokines expression like phenotype modulation in rats fed a high fat diet. Life Sci. 2016;165:100

Eaton M, Granata C, Barry J, Safdar A, Bishop D, Little JP. Impact of a single bout of high-intensity interval exercise and short term interval training on FNDC5, and METRNL mRNA expression in human skeletal muscle. [Internet] 2017 [cited 2017 Mar 14];Available from:

Chen N, Li Q, Liu J, Jia S. Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review. Diabetes Metab Res Rev latihan fisik pada eige 446–54. pokok-pokok hasil Riau. 2013; physical Public Health Rep. and brown adiposelike high-100–8. shortterm interleukin-6, J Sport Health Sci Rev. 2016;32(1):51–9.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1 myokine that drives brown development of white fat and thermogenesis. Nature. 2012;481(7382):463–8.

Lizcano F, Vargas D. Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity. Int J Endocrinol 2016;2016:1–10.

Giralt M, Cairó M, Villarroya F. Hormonal and nutritional signalling in the control of brown and beige adipose tissue activation and recruitment. Best Pract Res Clin Endocrinol Metab. 2016;30(4):515

Elsen M, Raschke S, Eckel J. Browning of white fat: does irisin play a role in humans? J Endocrinol. 2014;222(1):R25

Giralt M, Villarroya F. White, brown, beige/brite: Different adipose cells for different functions?. 2013;154(9):2992–3000.

Crichton PG, Lee Y, Kunji ERS. The molecular features of uncoupling support a conventional mitochondrial carrier-like mechanism. 2017;134:35–50.

Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med. 2013;19(10):1252

Perakakis N, Triantafyllou GA, Fernánd Real JM, Huh JY, Park KH, Seufert J, et al. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol 2017 [cited 2017 Mar 9];advance online publication. Available from:

Buscemi S, Corleo D, Buscemi C, Giordano C. Does iris(in) bring bad news or good news?. Eat Weight Disord. 201

de Macêdo SM, Lelis D de F, Mendes KL, Fraga CA de C, Brandi IV, Feltenberger JD, et al. Effects of Dietary Macronutrient Composition on FNDC5 and Irisin in Mice Skeletal Muscle. Metab Syndr Relat Disord 2017;15(4):161–9.

Kartinah NT, Rosalyn Sianipar I, Rabia. The Effects of Exercise Regimens on Irisin Levels in Obese Rats Model: Comparing High-Intensity Intermittent with Continuous Moderate-Intensity Training. Bio Med Res Int. 2018;2018:1–

Ferraro E, Giammarioli AM, Chiandotto S, Spoletini I, Rosano G. Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy. Antioxid Redox Signal. 2014;21(1):154-76.

Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38.

Jeon S-M. Regulation and function of AMPK in physiology diseases. Exp Mol Med. 2016;48(7):e245-e245.

Lally JSV, Ford RJ, Johar J, Crane JD, Kemp BE, Steinberg GR. Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression. Physiol Rep. 2015;

Schnyder S, Handschin C. Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise. Bone [Internet] 2015 [cited 2017 Nov 13];80:115-25. Available from:

Ge X, Sathiakumar D, Lua BJG, Kukreti H, Lee M, McFarlane C. Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes. Int J Obes [Internet] 2017 [cited 2017 Nov 13];41(1):137-48. from:

Rabia, Neng Tine Kartinah, Nurul Paramita, Nafi’ah, Imelda Rosalyn Sianipar. Exercise Formula to Induce Beiging Process: A Study Based on Acute Response of Irisin. Proc Surabaya Int Physiol Semin. 2017;1:248-51.

Winn NC, Grunewald ZI, Liu Y, Heden TD, Nhyoff LM, Kanaley JA. Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females. PloS One. 2017;12(1):e0170690.

Tsuchiya Y, Ando D, Goto K, Kiuchi M, Yamakita M, Koyama K. High-Intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumtion. Tohoku J Exp Med. 2014;233(2):135-40.

Huh JY, Siopi A, Mougios , Park KH, Mantzoros CS. Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome. J Clin Endrocrinol Metab. 2015;100(3):E453-7.

Eaton M, Granata C, Barry J, Safdar A, Bishop D, Little JP. Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle. J Sport Health Sci. 2018;7(2):191-196.

Kim H-J, Lee H-J, So B, Son JS, Yoon D, Song W. Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overwight/obese adults: a pilot study. Physiol Res. 2016;65(2):271.

Zhao J, Su Z, Qu C, Dong Y. Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults. Front Physiol [Internet] 2017 [cited 2019 Jan 21];8 Available from:

Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, et al. The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS J. 2014;281(3):739-49.



  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.